NWO Physics Valorisation Prize goes to Ron Heeren from Maastricht Universitynovember 18, 2019
This year, the prize for the best knowledge utilisation in physics goes to Prof. Ron Heeren (M4I). He works on improving clinical diagnostics by means of mass spectrometry imaging. He implemented a method at Maastricht UMC+ that allows the surgeon to see, during the operation, whether the edge of the tissue excised is also free of tumour cells. The NWO Physics Valorisation Prize is worth 250,000 euros and is intended to encourage knowledge utilisation in physics. Ron Heeren receives the prize for his successful translation of physics research to the market and for his contribution to patient diagnostics.
Heeren is the director of M4I, the Maastricht Multimodal Molecular Imaging Institute, and university professor at Maastricht University. He gained his doctorate in 1992 from the University of Amsterdam and led a research group at AMOLF. Although being trained as a technical physicist, he now focuses on the biomedical applications of mass spectrometry. ‘That is what makes my type of research that cuts across disciplines so much fun, physics that makes a difference for the patient.’
Heeren and his team developed innovative instruments and methods for mass spectrometry imaging. This technique can be used to localise and identify different molecules and isotopes in biological and chemical surfaces and to subsequently determine the quantities in which they are present. The techniques that Heeren has developed turn a routine mass spectrometer into a genuine molecular microscope, which can map the molecular complexity of surfaces. That could be tissue surfaces from the operating theatre, soil samples, paint samples from paintings, polymer fibres from DSM, et cetera. The techniques can be used on everything where a chemical analysis with an X and Y coordinate is necessary.
From CERN to surgeon
Heeren’s research focuses on the molecular basis for a personal treatment plan that he wants to make faster, more precise, more personal and even preventative with the help of molecular diagnosis. The selection committee noticed his broad outlook in continually identifying and elaborating new applications. He has taken the Medipix technology, developed by the particle accelerator CERN, and further developed this into an application the pathologist can use to establish a diagnosis during the operation, which is based on detailed molecular information. This data is used to construct tissue models that a surgeon can use while excising a tumour to determine whether the edge of the material excised (the tumour margin) is free of tumour cells. This is crucial because, otherwise, the tumour can return again: in 20 percent of cases, the patient has to come back for a second operation. Heeren also contributed to the clinical implementation of an intelligent surgical knife, the iKnife, which analyses smoke during an operation and can establish a diagnosis within a few seconds. That means the surgeon can immediately remove all malignant cells during the first operation.
From the jury report: ‘Another example of his innovative talent is the development of a method to elucidate molecular structures with a resolving power of 150 nanometres. An American company has translated the method into a commercial instrument for the chemical and automotive industries, which is an example of Heeren’s successful international public-private valorisation.
The different collaborative partners illustrate the diversity and effectiveness of Heeren’s valorisation-focused research: from companies such as ThermoFisher Scientific to institutions such as Maastricht UMC. Ron Heeren has also established successful companies such as Omics2Image and The Dutch Screening Group. Several of the nine patents that he has acquired so far have been taken over by companies active in the scientific instrument market. He has passed on his knowledge of and commitment to valorisation to others in Maastricht through giving the course ‘Entrepreneurial awareness’, which he set up for his team.’
Ron Heeren: ‘For me personally, it is, of course, a tremendous honour, but above all else a recognition of all the researchers, companies and investors who over the years have contributed to the fundamental, instrumentation and applied research at the boundary of various disciplines. The physical technologies we have developed here at Maastricht University and in the past at AMOLF are now finding applications in the operating theatres of Maastricht University Hospital.’
The NWO Physics Valorisation Prize
The aim of the NWO Physics Valorisation Prize is to encourage the utilisation of knowledge from research in physics. NWO awards the prize of 250,000 euros to a researcher or research group working in the field of physics in the Netherlands that has managed to turn the results of their own research into something useful for society. From the total prize money, 235,000 euros is earmarked for new research – to be determined by the winner – for a period of two to four years. The winner is free to use the remaining 15,000 euros as he or she wishes. Heeren will receive the prize during the annual meeting of physicists Physics@veldhoven on 21 and 22 January 2020.